The role of Helicobacter pylori in functional dyspepsia

We present a narrative review that analyzes the role played by Helicobacter pylori infection in the pathophysiology of functional dyspepsia, presenting current evidence on this relationship. It highlights the importance of diagnosing and treating the infection when it is present in these patients, using the appropriate non-invasive diagnostic tests and selecting the best therapeutic scheme, recognizing that the eradication of H. pylori only achieves remission or improvement of symptoms in a subgroup of patients with functional dyspepsia. This review acknowledges the current challenges in the treatment of the bacterium, particularly in relation to the growing antibiotic resistance and its clinical impact, and discusses some of the options that could increase eradication rates in patients, highlighting the relevance of susceptibility-based treatments. Finally, the importance of confirming the success of the post-eradication treatment is highlighted.