Endoscopic treatment of gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is a highly prevalent condition and one of the most frequent causes of medical consultation. Traditional treatments consist of life-style changes, pharmacologic and surgical treatments. In recent years, various endoscopic treatments for GERD have been described and studied, and some of them have emerged as safe and effective alternatives to conventional treatments. The most studied are radiofrequency application to the gastroesophageal junction, incisionless transoral fundoplication, endoscopic suturing of the esophagogastric junction, and other novel techniques such as endoscopic transmural plication, endoscopic mucosal ablation, and endoscopic mucosal resection. This article discusses the scientific evidence on the indications, outcomes, adverse events, and role of the various endoscopic treatments for GERD treatments.